Table 1. Mean age and percentage of participants ≥ 75 years old in pivotal studies of NOACs.

	RE-LY[18] Dabigatran			ROCKET-AF[19] Rivaroxaban		ARISTOTLE[20] Apixaban		ENGAGE AF-TIMI 48[21] Edoxaban
	D150 mg (n = 6076)	D110 mg (n = 6015)	W (n = 6022)	R (n = 7131)	W (n = 7133)	A (n = 9120)	W (n = 9081)	E60 mg (n = 7035)	E30 mg (n = 7034)	W (n = 7036)
Age (years)	71.5 ± 8.8	71.4 ± 8.6	71.6 ± 8.6	73 (65–78)	73 (65–78)	70 (63–76)	70 (63–76)	72 (64–68)	72 (64–78)	72 (64–78)
≥75 yrs	40%	38%	39%	43%	43%	31%	31%	41%	40%	40%

A: apixaban; D: dabigatran; E: edoxaban; NOACs: new oral anticoagulants; R: rivaroxaban; W: warfarin.