Table 3.
Association of MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G polymorphisms with Liver Cirrhosis, adjusted for gender, age, smoking and alcohol consumption
| Model | Genotipe | Control n (%) | Case n (%) | 1OR (95%CI) | 2P-value | Genotipe | Control n (%) | Case n (%) | 1OR (95%CI) | 2P-value |
| MTHFR C677T | MTHFR A1298C | |||||||||
| Codominant | C/C | 149 (41.9) | 48 (41.4) | 1 | A/A | 205 (57.6) | 57 (49.1) | 1 | ||
| C/T | 174 (48.9) | 55 (47.4) | 0.90 (0.56-1.45) | 0.56 | A/C | 116 (32.6) | 43 (37.1) | 1.27 (0.78-2.07) | 0.21 | |
| T/T | 33 (9.3) | 13 (11.2) | 1.37 (0.64-2.95) | C/C | 35 (9.8) | 16 (13.8) | 1.85 (0.92-3.71) | |||
| Dominant | C/C | 149 (41.9) | 48 (41.4) | 1 | A/A | 205 (57.6) | 57 (49.1) | 1 | ||
| C/T-T/T | 207 (58.1) | 68 (58.6) | 0.97 (0.62-1.52) | 0.89 | A/C-C/C | 151 (42.4) | 59 (50.9) | 1.40 (0.90-2.18) | 0.14 | |
| Recessive | C/C-C/T | 323 (90.7) | 103 (88.8) | 1 | A/A-A/C | 321 (90.2) | 100 (86.2) | 1 | ||
| T/T | 33 (9.3) | 13 (11.2) | 1.45 (0.71-2.99) | 0.32 | C/C | 35 (9.8) | 16 (13.8) | 1.68 (0.86-3.29) | 0.14 | |
| Overdominant | C/C-T/T | 182 (51.1) | 61 (52.6) | 1 | A/A-C/C | 240 (67.4) | 73 (62.9) | 1 | ||
| C/T | 174 (48.9) | 55 (47.4) | 0.85 (0.54-1.33) | 0.47 | A/C | 116 (32.6) | 43 (37.1) | 1.14 (0.72-1.82) | 0.58 | |
| Aditive | --- | --- | --- | 1.07 (0.75-1.51) | 0.72 | --- | --- | --- | 1.33 (0.97-1.83) | 0.079 |
| MTR A2756G | MTRR A66G | |||||||||
| Codominant | A/A | 263 (73.9) | 79 (68.1) | 1 | A/A | 105 (29.5) | 37 (31.9) | 1 | ||
| A/G | 83 (23.3) | 32 (27.6) | 1.52 (0.91-2.53) | 0.13 | A/G | 179 (50.3) | 55 (47.4) | 0.94 (0.56-1.56) | 0.95 | |
| G/G | 10 (2.8) | 05 (4.3) | 2.47 (0.75-8.12) | G/G | 72 (20.2) | 24 (20.7) | 0.91 (0.49-1.71) | |||
| Dominant | A/A | 263 (73.9) | 79 (68.1) | 1 | A/A | 105 (29.5) | 37 (31.9) | 1 | ||
| A/G-G/G | 93 (26.1) | 37 (31.9) | 1.60 (0.98-2.61) | 0.06 | A/G-G/G | 251 (70.5) | 79 (68.1) | 0.93 (0.58-1.50) | 0.77 | |
| Recessive | A/A-A/G | 346 (97.2) | 111 (95.7) | 1 | A/A-A/G | 284 (79.8) | 92 (79.3) | 1 | ||
| G/G | 10 (2.8) | 5 (4.3) | 2.19 (0.68-7.09) | 0.21 | G/G | 72 (20.2) | 24 (20.7) | 0.95 (0.55-1.64) | 0.86 | |
| Overdominant | A/A-G/G | 273 (76.7) | 84 (72.4) | 1 | A/A-G/G | 177 (49.7) | 61 (52.6) | 1 | ||
| A/G | 83 (23.3) | 32 (27.6) | 1.46 (0.88-2.41) | 0.15 | A/G | 179 (50.3) | 55 (47.4) | 0.97 (0.62-1.52) | 0.9 | |
| Aditive | --- | --- | --- | 1.54 (1.02-2.33) | 0.042 | --- | --- | --- | 0.95 (0.70-1.30) | 0.77 |
1
Odds ratio (OR) adjusted for age, gender and alcohol consumption and smoking habits;
2
P values significant at P ≤ 0.05.