Table 4.
Interaction between MTHFR C677T, MTHFR A1298C, MTR A2756G and MTRR A66G polymorphisms and smoking habits or alcohol drinking on the risk of hepatocellular carcinoma
|
Smoking habits |
Alcoholic habit |
|||||||||||||
|
No smoker |
Smoker |
2P interaction |
Non-alcoholic |
Alcoholic |
2P interaction | |||||||||
| Case | Control | 1OR (95%CI) | Case | Control | 1OR (95%CI) | Case | Control | 1OR (95%CI) | Case | Control | 1OR (95%CI) | |||
| MTRA2756G | ||||||||||||||
| A/A | 22 | 142 | 1.00 | 24 | 121 | 1.00 | 0.81 | 17 | 137 | 1.00 | 29 | 126 | 1.00 | 0.43 |
| A/G-G/G | 10 | 57 | 1.59 (0.65-3.87) | 15 | 36 | 1.85 (0.81-4.21) | 11 | 53 | 2.29 (0.91-5.72) | 14 | 40 | 1.40 (0.63-3.12) | ||
| MTRRA66G | ||||||||||||||
| A/A | 4 | 55 | 1.00 | 8 | 50 | 1.00 | 0.7 | 3 | 53 | 1.00 | 9 | 52 | 1.00 | 0.34 |
| A/G-G/G | 28 | 144 | 3.04 (0.95-9.71) | 31 | 107 | 2.27 (0.90-5.72) | 25 | 137 | 4.16 (1.11-15.55) | 34 | 114 | 1.98 (0.83-4.75) | ||
| MTHFRC677T | ||||||||||||||
| C/C | 15 | 85 | 1.00 | 13 | 64 | 1.00 | 0.55 | 14 | 85 | 1.00 | 14 | 64 | 1.00 | 0.75 |
| C/T-T/T | 17 | 114 | 0.80 (0.35-1.81) | 26 | 93 | 1.13 (0.51-2.52) | 14 | 105 | 0.86 (0.36-2.06) | 29 | 102 | 1.04 (0.48-2.22) | ||
| MTHFRA1298C | ||||||||||||||
| A/A | 13 | 119 | 1.00 | 19 | 85 | 1.00 | 0.61 | 11 | 113 | 1.00 | 21 | 91 | 1.00 | 0.56 |
| A/C-C/C | 19 | 80 | 2.00 (0.88-4.56) | 20 | 72 | 1.49 (0.69-3.20) | 17 | 77 | 2.10 (0.86-5.10) | 22 | 75 | 1.49 (0.72-3.07) | ||
1
Odds ratio (OR) adjusted for age, gender and alcohol consumption and smoking habits;
2
P values significant at P ≤ 0.05.