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. 2016 Oct 18;6:35228. doi: 10.1038/srep35228

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Copyright © 2016, The Author(s)

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(A) rs7636 is in perfect LD with rs11171 (SRRT), rs781190 and rs1716255 (SLC12A9) in Beijing Han Chinese in the CSHL-HapMap project (r2: 1; D’:1). Both SRRT (log2fold -0.88, adjusted p: 1.24E-4) and SLC12A9 (log2fold -0.77, adjusted p: 6.32E-3) were significantly down-regulated in T2D. Expression of ACHE was not altered (log2fold 0.19, adjusted p: 1.00). (B) The dysregulation of expression of SRRT and SLC12A9 were replicated in the independent cohort. Statistical significance in change of gene expression: * p < 0.05, **p < 0.01, ***p < 0.001. (C) Physical interaction of SRRT, JAZF1 and CREB5 among other proteins.