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. 2016 Oct 18;6:35478. doi: 10.1038/srep35478

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Copyright © 2016, The Author(s)

This work is licensed under a Creative Commons Attribution 4.0 International License. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in the credit line; if the material is not included under the Creative Commons license, users will need to obtain permission from the license holder to reproduce the material. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/

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Mouse interdigital cells at day 13.5 pc immunolabeled for γH2AX (A–C) in combination with MDC1 (A´), RAD50 (B´) and 53BP1 (C´) to show the activation of DDR mediators prior to overt cell degeneration. A´´, B´´, and C´´ are merged images. (D) Pixel intensity plot of the region indicated by red arrow showing the labeling distribution of 53BP1 (red) and γH2AX (green) in an interdigital cell similar to that shown in (C) Note the presence of isolated γH2AX foci and a region of colocalization with 53BP1. (E) Chick interdigital cells at id 6 immunolabeled for γH2AX (E) and pATM (E´). E´´ is the merged image. Inset is a detailed view of the cell indicated by asterisk. Bars in (A–C) = 10 μm; bar in (E) = 30 μm.