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. 2016 Oct 18;4:110. doi: 10.3389/fcell.2016.00110

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Copyright © 2016 Itoh, Ohta, Nakayama and Konishi.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Evolutionary relationships within the human FGF family. Phylogenetic analyses suggest that 22 members of the FGF family are classified into several subfamilies. Branch lengths are proportional to the evolutionary distance between each FGF. FGFs are also classified into paracrine, endocrine, and intracrine FGFs based on their mechanisms of action (Ornitz and Itoh, 2015; Brewer et al., 2016). FGF2, FGF3, FGF8, FGF9, FGF10, FGF15/19, FGF16, FGF21, and FGF23 play roles in heart development, health, and disease. This figure is adapted from Itoh et al. (2016).

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