Table 1.

Developmental roles of FGFs in the embryonic mouse heart.

	Function	Heart phenotype
PARACRINE SIGNAL
FGF8	Loss-of-function	Defect in cardiac looping, the cardiac outflow tract, and anterior heart field development
	Loss-of-function	Decrease in migratory cardiac neural crest survival
FGF9	Loss-of-function	Decrease in cardiomyocyte proliferation
FGF10	Loss-of-function	Decrease in cardiomyocyte proliferation
	Loss-of-function	Decrease in cardiac fibroblast migration
FGF10/FGF3	Loss-of-function	Defect in cardiovascular progenitor cell development
FGF10/FGF8	Loss-of-function	Defect in outflow tract and right ventricle development
FGF15/19	Loss-of-function	Defect in cardiac outflow tract development
FGF16	Loss-of-function	Decrease in cardiomyocyte proliferation
	Loss-of-function	Defect in chamber, atrial, and ventricular walls and trabeculation