Table 2.

Pathophysiological roles of FGFs in the postnatal mouse heart.

	Function	Heart phenotype
PARACRINE SIGNAL
FGF2	Loss-of-function	Protection against induced cardiac hypertrophy and fibrosis Promotion of cardiac ischemia-reperfusion injury
	Gain-of-function	Promotion of cardiac hypertrophy
FGF9	Gain-of-function	Improvement in heart function
	Gain-of-function	Protection against heart injury
FGF10	Gain-of-function	Protection against heart injury
	Gain-of-function	Promotion of cardiomyocyte proliferation
FGF16	Loss-of-function	Promotion of induced cardiac hypertrophy and fibrosis
FGF21	Loss-of-function	Promotion of induced cardiac hypertrophy and inflammation
ENDOCRINE SIGNAL
FGF21	Gain-of-function	Protection against cardiac dysfunction and inflammation
	Loss-of-function	Promotion of cardiac dysfunction and inflammation