Table 4. Relationships between Polymorphisms of SLC19A1, FPGS, or GGH and adverse events stratified by genotype.
| genotype | AE(−) group | AE (+) group | P value | ||
|---|---|---|---|---|---|
| SLC19A1 | rs1051266 | 80G > A | GG/AG/AA | GG/AG/AA | p = 0.139 |
| 68/93/27 | 26/37/20 | ||||
| FPGS | rs10106 | 1994A > G | AA/AG/GG | AA/AG/GG | p = 0.952 |
| 91/78/19 | 39/37/7 | ||||
| rs1054774 | 11694T > A | TT/AT/AA | TT/AT/AA | p = 0.289 | |
| 73/89/26 | 40/38/10 | ||||
| rs1544105 | 2572C > T | CC/CT/TT | CC/CT/TT | p = 0.327 | |
| 93/80/15 | 35/40/8 | ||||
| GGH | rs719235 | 452C > T | CC/CT/TT | CC/CT/TT | p = 0.688 |
| 151/32/5 | 65/15/3 | ||||
| rs1800909 | −401C > T | CC/CT/TT | CC/CT/TT | p = 0.477 | |
| 7/22/159 | 5/14/64 | ||||
| rs3758149 | −354G > T | GG/GT/TT | GG/GT/TT | p = 0.125 | |
| 121/61/6 | 56/23/4 | ||||
| rs11545078 | 16T > C | TT/CT/CC | TT/CT/CC | p = 0.582 | |
| 163/25/0 | 70/12/1 | ||||
| rs12681874 | 14269G > A | GG/AG/AA | GG/AG/AA | p = 0.174 | |
| 61/92/39 | 20/42/21 |
p values for comparisons between the AE (+) and AE (−) groups were evaluated by the Kruskal-Wallis test.
SLC19A1: reduced folate carrier 1, FPGS: folylpolyglutamyl synthase, GGH: gamma-glutamyl hydrolase.