Figure 2.

Implication of RNA-mediated regulation in pathogenesis of intracellular bacteria. (A) The regulatory cascade of Salmonella is composed of sRNAs, RfrA and RfrB, plays vital role in the establishment of Salmonella-containing vacuole (SCV), which facilitates adoption of pathogen within host cell resulting in regulation of iron homeostasis, oxidative stress, and acid resistance. (B) The regulatory sRNAs, RsmY and RsmZ, control the action of effectors secreted in cytosol of host which helps in establishing the Legionella-containing vacuole (LCV). (C) The regulatory sRNAs, AbcR1 and AbcR2, interact with hfq to modulate the virulence and intracellular survival of Brucella.