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. 2016 Oct 18;6:35610. doi: 10.1038/srep35610

Figure 5. LPS-TLR4 induced liver damage is mediated by ductular cells in animal models of liver injury.

Figure 5

(a) Gene expression of Krt23 and LPCs markers (Krt7 and Epcam) in WT and Tlr4-KO mice subjected to sham operation (n = 3) or BDL. BDL mice were sacrificed 5 (n = 4) or 21 days (n = 8) after operation. (b) Representative micrographs of KRT23 protein expression in WT and Tlr4-KO mice subjected to sham operation or BDL. (c) Gene expression of Krt23 and LPCs markers in WT and Tlr4-KO mice subjected to Tsukamoto-French model of ethanol damage (4 weeks, n = 6) compared to uninjured control mice (n = 4). (d) Representative micrographs of Krt23 protein expression in WT and Tlr4-KO mice subjected to Tsukamoto-French model and uninjured control mice. Bars, 100 μm.

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