Table 3.
BKPyV EVGR‐specific T cell responses in kidney transplant recipients
| IFN‐γ ELISpot | MHC‐streptamers | ||||||
|---|---|---|---|---|---|---|---|
| HLA type | BKPyV epitope | Tested KTRs (n) | KTRs with positive response (%) | SFU/106 cells (mean) | Tested KTRs (n) | KTRs with positive response (%) | Epitope‐specific CD8+ T cells (mean %) |
| A*01 | 256 | 2 | 50 | 100 | – | – | – |
| 327 | 2 | 100 | 40 | 3 | 67 | 0.10 | |
| 386 | – | – | – | 3 | 33 | 0.02 | |
| A*02 | 316 | – | – | – | 5 | 20 | 0.14 |
| 302 | 8 | 12 | 245 | – | – | – | |
| 389 | 9 | 67 | 312 | – | – | – | |
| 391 | 4 | 25 | 840 | – | – | – | |
| 393 | – | – | – | 3 | 33 | 0.06 | |
| 510 | 10 | 50 | 95 | – | – | – | |
| 536 | – | – | – | 4 | 25 | 0.14 | |
| 679 | 9 | 89 | 324 | 11 | 36 | 0.09 | |
| A*03 | 256 | 3 | 30 | 120 | – | – | – |
| 272 | – | – | – | 3 | 67 | 0.12 | |
| 327 | 3 | 30 | 270 | 1 | 100 | 0.05 | |
| A*11 | 256 | 3 | 30 | 120 | – | – | – |
| 276 | 3 | 30 | 465 | – | – | – | |
| 327 | 3 | 67 | 270 | 3 | 33 | 0.08 | |
| 389 | 3 | 33 | 70 | – | – | – | |
| A*24 | 127 | 3 | 33 | 200 | – | – | – |
| 342 | – | – | – | 1 | 100 | 0.08 | |
| 389 | 4 | 50 | 370 | 2 | 50 | 0.02 | |
| B*07 | 119 | 2 | 50 | 130 | 2 | 50 | 0.07 |
| 127 | 2 | 100 | 280 | 2 | 50 | 0.08 | |
| 240 | – | – | – | 1 | 100 | 0.03 | |
| 301 | – | – | – | 1 | 100 | 0.09 | |
| 389 | 2 | 50 | 285 | – | – | – | |
| B*08 | 127 | 1 | 100 | 150 | – | – | – |
| 462 | – | – | – | 1 | 100 | 0.08 | |
| 679 | – | – | – | 1 | 100 | 0.07 | |
| B*35 | 240 | 5 | 80 | 410 | – | – | – |
| 391 | 5 | 40 | 590 | – | – | – | |
| 633 | 5 | 40 | 145 | – | – | – | |
| B*51 | 256 | 4 | 25 | 180 | – | – | – |
| 389 | 5 | 40 | 135 | 2 | 50 | 0.10 | |
| 506 | 2 | 100 | 175 | – | – | – | |
BKPyV, BK polyomavirus; EVGR, early viral gene region; IFN‐γ, interferon γ; KTR, kidney transplant recipient; SFU, spot‐forming unit.