FIG 8.

Impact of neutrophil depletion on the outcome of Y. enterocolitica ΔyopH infection. Neutrophil-depleted mice were injected intraperitoneally with 100 μg of the monoclonal anti-Gr1antibody (clone RB6-8C5) 1 day before and on days 2 and 3 after intragastric Y. enterocolitica ΔyopH infection. Control mice received the same dosage of saline. Bacterial loads (CFU) in the Peyer's patches (PP) (A) and spleen (B) of neutrophil-depleted mice (Ye ΔyopH + RB6-8C5) and control mice (Ye ΔyopH) were assessed at day 3 after infection with Y. enterocolitica ΔyopH. Each symbol represents an individual mouse; horizontal lines indicate the means. ***, P < 0.001.