FIG 8.

E. chaffeensis TRP32 binds to noncoding RNA genes in the host cell. (A) TRP32 targets include RNA-coding genes. When all significant TRP32 bound regions of chromatin were examined, 24% mapped to RNA-coding genes. When the RNA-coding genes were examined, the majority were snoRNAs (33%) followed by miRNAs (29%), antisense RNAs (17%), and noncoding RNAs (17%). A small percentage corresponded to pseudogenes (4%). (B) A table of the characterized noncoding RNAs bound by TRP32 shows that many are involved in cell fate determination: NR_027349 (51, 52); NR_029493 (53–55); NR_029683 (56–59); NR_002819 (60, 61); NR_029779 (62–64); NR_030230 (65).