Table 1.

Genomic Variants that Influence Pain in Sickle Cell Disease

Gene	SNPS	Chromosomes locus	Association	References
OPRM1	rs1799971	6:154039662	Pain	Joly et al. (2012); Jhun et al. (2015)
HMOX-1	A(GT) VNTR	Chromosome 22	Vaso-occlusive crises	Bean et al. (2013)
GCH1	rs8007267	14:54912273	Pain	Belfer et al. (2014)
COMMD7	rs614803	18:79389574	Painful crisis	Galarneau et al. (2013)
GSTM1	GSTM1 null allele	Chromosome 1	Severe vaso-occlusive crisis	Shiba et al. (2014)
MTHFR	rs1801133 (C677T)	1:11796321	Pain	Nishank et al. (2013)
FVL	rs6025 (G1691A; R506Q)	1:169549811	Pain	Nishank et al. (2013)
VEGFA	rs833068 (G398A)	6:43774790	Vaso-occlusive crisis	Al-Habboubi et al. (2012)
VEGFA	rs2010963	6:43770613	Vaso-occlusive crisis	Al-Habboubi et al. (2012)
VEGFA	rs3025020	6:43781373	Vaso-occlusive crisis	Al-Habboubi et al. (2012)
CYP2D6	rs1065852	22:42130692	Pain and drug metabolism	Joly et al. (2012); Jhun et al. (2015)
COMT	rs4633	22:19962712	Pain	Joly et al. (2012); Jhun et al. (2015)
	rs6269	22:19962429	Pain
	rs737865	22:19942598	Pain
CPY3A	rs1057868	7:75985688	Pain	Joly et al. (2012); Jhun et al. (2015)
UGTB7	rs1799971	6:154039662	Pain	Joly et al. (2012); Jhun et al. (2015)
ABCB1	rs1045642	7:87509329	Pain	Jhun et al. (2015)