Table 1.
Differential metabolites for discrimination among lipopolysaccharide (LPS), LPS group treated with PM (LPM), and LPS group co-treated with PM + middle dose of Poria (LPMP) groups.
| No. | Metabolite | Mass | tR/min | Formula | LPM/LPS | LPMP/LPM | ||||
|---|---|---|---|---|---|---|---|---|---|---|
| VIP | Fold | p | VIP | Fold | p | |||||
| ESI+ mode | ||||||||||
| 1 | Creatine | 131.0692 | 0.82 | C4H9N3O2 | 1.67 | 0.63 | 0.0084 | 1.53 | 1.70 | 0.0254 |
| 2 | Arginine | 174.1124 | 0.93 | C6H14N4O2 | 5.55 | 0.52 | 0.0052 | 5.76 | 1.92 | 0.0004 |
| 3 | Sphingosine | 299.2812 | 13.44 | C18H37NO2 | 1.12 | 2.58 | 0.0086 | 1.11 | 0.45 | 0.0142 |
| 4 | Sphinganine 1-phosphate | 381.2663 | 19.72 | C18H40NO5P | 1.29 | 0.43 | 0.0194 | 1.21 | 2.08 | 0.0009 |
| 5 | Disopyramide | 339.2319 | 19.92 | C21H29N3O | 1.08 | 0.22 | 0.0140 | 0.93 | 3.63 | 0.0030 |
| 6 | Adrenoyl ethanolamide | 375.3123 | 21.08 | C24H41NO2 | 1.61 | 0.47 | 0.0080 | 1.62 | 2.10 | 0.0009 |
| ESI- mode | ||||||||||
| 7 | Ornithine | 132.0853 | 1.05 | C5H12N2O2 | 5.83 | 0.48 | 0.0005 | 5.56 | 1.77 | 0.0106 |
| 8 | 4-Amino-butyraldehyde | 87.0684 | 1.28 | C4H9NO | 1.01 | 0.37 | 0.0022 | 1.14 | 2.52 | 0.0049 |
| 9 | 4-Pyridoxic acid | 183.0502 | 1.36 | C8H9NO4 | 2.22 | 0.58 | 0.0168 | 1.92 | 1.55 | 0.0941 |
| 10 | 4-Acetamid-obutanoate | 145.0739 | 1.77 | C6H11NO3 | 2.44 | 0.52 | 0.0114 | 1.27 | 1.42 | 0.2873 |
| 11 | Phenyl sulfate | 174.0012 | 5.58 | C6H6O4S | 3.25 | 0.17 | 0.0400 | 1.72 | 3.36 | 0.7962 |
| 12 | Uridine | 122.0321 | 5.75 | C9H12N2O6 | 1.47 | 2.06 | 0.0315 | 2.24 | 0.37 | 0.0141 |
| 13 | Taurocholate | 515.2905 | 7.75 | C26H45NO7S | 1.04 | 2.66 | 0.0460 | 1.32 | 0.32 | 0.0317 |
| 14 | Glycocholate | 465.3040 | 8.17 | C26H43NO6 | 1.17 | 1.95 | 0.0491 | 1.33 | 0.52 | 0.0361 |