Table 1.
Organism | Bacterial Protease | MEROPS Family | Protease Class | Substrate | Associated Process | References |
---|---|---|---|---|---|---|
P. aeruginosa | Elastase A (LasA) | M23 | Metallo- | Fibrinogen, elastin | ECM destruction | 16,52 |
Elastase B (Las B) | M4 | Metallo- | Elastin, collagen III, collagen IV, MMP-1/MMP-9 (proenzyme), elastase B | ECM destruction, MMP proteolysis, autoproteolytic processing | 16,53 | |
Alkaline protease (AprA) | M10 | Metallo- | Fibrinogen, gelatin, casein, hemoglobin, cytokines | Complement inactivation, host immune evasion | 16,54,55 | |
Protease IV | S1 | Serine- | Plasminogen, fibrinogen, complement protein C3 | Complement inactivation | 16,56 | |
S. aureus | Aureolysin | M4 | Metallo- | Plasminogen, complement protein C3 | Complement inactivation | 16,23,57 |
Staphopain A (ScpA) | C47 | Cysteine- | Elastin | ECM destruction | 16 | |
Staphopain B (SspB) | C47 | Cysteine- | Fibrinogen, fibronectin, elastin | ECM destruction, complement inactivation | 16,57 | |
Staphylococcal serine protease (SspA) | S1 | Serine- | Actin, collagenase, IgG1 heavy chain, serum albumin, vimentin, casein | Host immune evasion, ECM degradation | 16,57,58 |
ECM, extracellular matrix; MMP, matrix metalloproteinase.