FIG. 5.

Anti-MRSA resistance of patient chimeras treated with HCA-11. Chimeras were created in γNSG mice after i.v. inoculation with 5 × 10⁶ cells/mouse healthy donor WBCs (healthy donors No. 1 − 5, healthy chimeras) or burn patient WBCs (burn patients No. 4 − 6, patient chimeras). Patient chimeras were treated with HCA-11 (25 μg/chimera, s.c.), scrambled ODN (25 μg/chimera, s.c.), or saline (0.2 mL, s.c.) twice a day for 2 days. Two days after the cell inoculation, these chimeras were infected with MRSA (10⁵ CFU/chimera, i.v.). Bacterial growth in the liver, spleen, and kidneys of chimeras was determined 3 days after the infection. Data are shown as mean ± SD. *P < 0.05 compared with chimera treated with saline.