Fig. 5.
Effect of CAE on the glutathione system in Aβ1–40-treated cells. Differentiated PC12 (A, C) and IMR32 cells (B, D) were treated with aggregated Aβ1–40 and CAE at indicated concentrations for 24 h, and GR (A, B) and GPx (C, D) activities were measured. GR and GPx activities are displayed as a percentage of the control. (E) The GSH/GSSG ratio in differentiated PC12 (■) and IMR32 (□) cells were measured at 24 h after cotreatment with CAE and aggregated Aβ1–40. In all experiments, cells left untreated served as controls. Values are expressed as mean ± SD (n = 6). *P < 0.05 compared to control, #P < 0.05 compared to Aβ1–40 treatment alone.