Table 3.

Functional Annotation of LASSO Biomarkers Associated with HEC Use

Accession	Description	Mean L2FD from baseline	SD	Function
SBSN	Suprabasin	−1.71	2.89	Epidermal differentiation
K2C4	Keratin, type II cytoskeletal 4	−1.50	1.02	Cytoskeletal component, structural protein
MUC2	Mucin-2	−1.45	2.51	Mucus component, cellular protein metabolism, maintenance of gastrointestinal epithelium, O-glycan processing
A1AG1	Alpha-1-acid glycoprotein 1	−1.40	1.12	Acute phase inflammation, regulation of IL6, regulation of TNF
FAM3D	Protein FAM3D	−1.22	1.95	Response to dietary fats, regulation of insulin secretion
ARF3	ADP-ribosylation factor 3	0.53	1.40	Protein transport, phospholipid metabolism, GTPase activity, small molecule metabolism, vesicle-mediated transport
MUC5A	Mucin-5AC	0.62	1.45	Mucus component, cellular protein metabolism, maintenance of gastrointestinal epithelium, O-glycan processing
KCRB	Creatine kinase B-type	0.80	1.05	Phosphate transfer, energy transfer, cellular chloride homeostasis, nitrogen metabolism, creating metabolic processes, small molecule metabolism
GDIR1	Rho GDP-dissociation inhibitor 1	0.91	1.00	Rho protein homeostasis, cellular response to redox state, regulation of apoptosis, regulation of cell adhesion, and migration, regulation of GTPase activity
SIAS	Sialic acid synthase	0.96	1.14	Cellular protein metabolism, lipid synthesis