Table 2.
Categorized pre-pregnancy maternal BMI and newborn telomere length
| Cord blood (n = 743) | Placenta (n = 702) | |||
|---|---|---|---|---|
| Percentage change (95 % CI) | P value | Percentage change (95 % CI) | P value | |
| Unadjusted | ||||
| <25 kg/m2 a | Ref | Ref | ||
| Overweightb | −3.0 (−6.1 to 0.3) | 0.07 | −4.2 (−7.9 to −0.3) | 0.03 |
| Obesec | −5.7 (−9.8 to −1.3) | 0.01 | −3.7 (−8.8 to 1.6) | 0.17 |
| Overweight + Obese | −3.8 (−6.5 to −1.0) | 0.008 | −4.1 (−7.3 to −0.7) | 0.02 |
| Model A | ||||
| <25 kg/m2 | Ref | Ref | ||
| Overweightb | −2.5 (−5.6 to 0.8) | 0.13 | −4.2 (−7.8 to −0.3) | 0.04 |
| Obesec | −5.2 (−9.3 to −0.9) | 0.02 | −3.6 (−8.7 to 1.8) | 0.19 |
| Overweight + Obese | −3.3 (−6.0 to −0.5) | 0.02 | −4.0 (−7.3 to −0.6) | 0.02 |
| Model B | ||||
| <25 kg/m2 | Ref | Ref | ||
| Overweightb | −2.5 (−5.6 to 0.8) | 0.14 | −4.6 (−8.4 to −0.7) | 0.02 |
| Obesec | −5.5 (−9.7 to −1.1) | 0.01 | −4.2 (−9.3 to 1.3) | 0.13 |
| Overweight + Obese | −3.4 (−6.2 to −0.5) | 0.01 | −4.5 (−7.8 to −1.0) | 0.01 |
Estimates are presented as a percentage change in average relative telomere length
Model A, adjustment for paternal and maternal age at birth, maternal education, newborn gender, gestational age, and birth weight. Model B, additionally adjusted for maternal smoking status, parity, newborn ethnicity, pregnancy complications, and cesarean section
a n = 488 for cord blood and n = 455 for placenta
b n = 175 for cord blood and n = 170 for placenta
c n = 80 for cord blood and n = 77 for placenta