Figure 4.

mRNA and protein expression of MCM2 and MCM3 in normal pancreas and pancreatic NENs (primaries and metastases).

(A) MCM2 and MCM3 mRNAs were elevated in metastases in comparison to normal pancreas and to primaries, whereas Ki67 was elevated in metastases compared to normal pancreas (Kruskal-Wallis P < 0.0001, *P < .05 versus normal, #P < .05 versus primaries). (B) Ki67 and MCM mRNA expression as a function of grade identified no significant differences in pancreatic NENs. (C) Using Western blot, an elevation of MCM protein expression in pNEN metastases was confirmed (Kruskal-Wallis, MCM2: P = .24, MCM3: P = .44). Mean ± SD.