. 2015 Sep 11;71(6):1004–1014. doi: 10.1093/geronb/gbv043

Table 4.

Statistical Results Relating Vascular Factors to Cognitive Status and Stability

Covariate	Wave	Status/Stability	Risk Factor	β	OR	95% CI	p
BMI	W1	MCI	>30kg/m²	-0.577	0.562	0.326–0.968	.019*
	W1-2	NIC-MCI	>30kg/m²	-0.143	0.867	0.338–2.220	.382
	W1-2	MCI-MCI	>30kg/m²	-0.474	0.623	0.300–1.292	.102
PEF	W1	MCI	Frail	0.393	1.481	0.921–2.381	.053
	W1-2	NIC-MCI	Frail	0.402	1.500	0.599–3.728	.195
	W1-2	MCI-MCI	Frail	0.339	1.281	0.640–2.567	.242
HBP	W1	MCI	History of HBP	-0.384	0.681	0.405–1.145	.074
	W1-2	NIC-MCI	History of HBP	-0.361	0.697	0.270–1.799	.228
	W1-2	MCI-MCI	History of HBP	-1.020	0.361	0.159–0.819	.008*
Pulse Rate	W1	MCI	>80 BPM	-0.227	0.797	0.399–1.592	.260
	W1-2	NIC-MCI	>80 BPM	0.685	1.983	0.667–5.899	.109
	W1-2	MCI-MCI	>80 BPM	-1.172	0.310	0.083–1.153	.040*
Heart Disease	W1	MCI	History of Heart Disease	-0.103	0.902	0.512–1.590	.360
	W1-2	NIC-MCI	History of Heart Disease	1.103	3.012	1.090–8.322	.017
	W1-2	MCI-MCI	History of Heart Disease	0.299	1.349	0.548–3.322	.258
Atherosclerosis	W1	MCI	History of Atherosclerosis	0.001	1.001	0.452–2.217	.499
	W1-2	NIC-MCI	History of Atherosclerosis	1.217	3.377	0.953–11.969	.030
	W1-2	MCI-MCI	History of Atherosclerosis	-0.585	0.557	0.111–2.799	.239
Stroke	W1	MCI	History of Stroke	-0.327	0.721	0.262–1.984	.263
	W1-2	NIC-MCI	History of Stroke	2.045	7.726	1.579–37.801	.006
	W1-2	MCI-MCI	History of Stroke	0.589	1.802	0.335–9.703	.247
Heart Medication	W1	MCI	History of Heart Meds	0.444	1.558	0.998–2.435	.025
	W1-2	NIC-MCI	History of Heart Meds	0.140	1.151	0.464–2.851	.381
	W1-2	MCI-MCI	History of Heart Meds	0.841	2.319	1.221–4.405	.005

Note: BMI = body mass index; HBP = high blood pressure; MCI = mild cognitive impairment; N = sample size; NIC = not impaired controls; OR = odds ratio; PEF = peak expiratory flow; W1 = Wave 1; W1-2 = Wave 1- Wave 2; p values are all presented as one-tailed; * = significant finding in the unexpected direction for BMI, HBP and pulse rate. The reference outcome groups are NIC (W1) and NIC-NIC (W1-2). For the self-reported variable analyses, the reference analysis groups consisted of those with no self-reported history. For the BMI, peak expiratory flow and pulse rate analyses, the reference analysis groups consisted of those with a normal range BMI, a normal range peak flow and a healthy pulse rate, respectively. Note, the same directionality was demonstrated for all analyses in the genotyped sample.