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. Author manuscript; available in PMC: 2017 Jul 25.
Published in final edited form as: Chem Soc Rev. 2016 Jul 25;45(15):4074–4126. doi: 10.1039/c5cs00287g

Figure 12. FA targeting for specific cell killing with Dox.

Figure 12

a) Schematic of formation of HCRSV-based protein cages without (PC-Dox) and with FA conjugation (fPC-Dox) where Dox is encapsulated during capsid reassembly with the inclusion of polyacid. b) Confocal microscopy of Dox uptake for OVCAR-3 ovarian cancer cells and CCL-186 fibroblast cells incubated with free doxorubicin, PC-Dox, fPC-Dox, and fPC-Dox in the presence of FA. c) Cell viability curves of cells after treatment with varying concentrations of the different formulations showing fPC-Dox had greater inhibition of OVCAR-3 cells without affecting pattern of CCL-186 inhibition. Reproduced with permission from ref. 184. Copyright 2007 American Chemical Society.