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. Author manuscript; available in PMC: 2017 Jul 25.
Published in final edited form as: Chem Soc Rev. 2016 Jul 25;45(15):4074–4126. doi: 10.1039/c5cs00287g

Figure 18. Manufacture of EBOV-TMV.

Figure 18

a) EBOV-TMV is manufactured by disassembly of TMV propagated in N. benthamiana plants into individual coat proteins that are then reassembled around synthetic RNA transcripts containing EBOV and TMV gene sequences. b) TEM of negatively-stained wild-type TMV rods. c) TEM of shorter EBOV-TMV rods demonstrating successful reconstitution. Scale bar = 100 nm. Reproduced with permission from ref. 423. Copyright 2016 Nature Publishing Group.