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. Author manuscript; available in PMC: 2017 Jul 25.
Published in final edited form as: Chem Soc Rev. 2016 Jul 25;45(15):4074–4126. doi: 10.1039/c5cs00287g

Figure 8. Targeted MR imaging of prostate cancer with M13.

Figure 8

a) Diagram of M13 structure with the major p8 proteins displaying a triglutamate motif for the multivalent display of iron oxide nanocrystals (black circles) and the p3 proteins at the end of the virus displaying SPARC binding peptide (pink) for targeting. b) MR scans of mice using a 7 T small animal MR scanner with subcutaneous C4-2B tumors (encircled) before (left) and 24 hours after (right) M13 injection displayed dark contrast from the targeted particles against the bright image of the tumor. Reproduced with permission from ref. 205. Copyright 2012 Nature Publishing Group.