Table 1.

Immunohistochemical expression of ADAM 10, 17 in cutaneous squamous cell carcinoma.

		ADAM 10
		Immunoreactivity
Variables		0	+	++	+++	P-value	Location in the cell
Normal epidermis (n = 5)		2	3	0	0		Cytoplasm
Differentiation	Well differentiated CSCC (n = 12)	4	4	4	0	*0.368	Cytoplasm
	Moderately differentiated CSCC (n = 7)	0	3	4	0	*0.021	Cytoplasm
	Poorly differentiated CSCC (n = 7)	0	2	2	3	*0.014	Cytoplasm
	Total (n = 26)	4	9	10	3	*.0045	–
										**0.017
					ADAM 17
		Immunoreactivity
Variables		0	+	++	+++	P-value	Location in the cell
Normal epidermis (n = 5)		1	4	0	0		Cytoplasm
Differentiation	Well differentiated CSCC (n = 12)	2	2	4	4	*0.063	Cytoplasm & Nucleus
	Moderately differentiated CSCC (n = 7)	0	2	5	0	* 0.015	Cytoplasm & Nucleus
	Poorly differentiated CSCC (n = 7)	0	2	4	1	* 0.017	Cytoplasm & Nucleus
	Total (n = 26)	2	6	13	5	* 0.012	–
										**0.093

a; ADAM 10, 17 positivity: +, weakly positive (1–20%); ++, moderately positive (21–50%), and +++, strongly positive (>50 %)

^*compared with normal epidermis

^**compared among 3 differentiated CSCC