Table 3.

Multi‐variate analysis: linear regression analysis for FGFR1 and 2 protein expression and logistic regression for FGFR3 protein expression with clinicopathological variables in non‐small cell lung cancer

Variable	FGFR1a	FGFR2a	FGFR3b
FGFR1a	NA	pos, p = 0.0005	pos p = 0.24
FGFR2a	pos, p = 0.0005	NA	neg p = 0.83
FGFR3b	pos, p = 0.21	neg, p = 0.61	NA
Genderc	pos, p = 0.46	pos, p = 0.01	neg, p = 0.69
Age at diagnosisd	pos, p = 0.50	neg, p = 0.26	pos, p = 0.17
Smoking statuse	neg, p = 0.17	pos, p = 0.58	pos, p = 0.008
SCC versus AC	neg, p = 0.002	neg, p < 10−7	pos, p < 10−6
LCC versus AC	neg, p = 0.47	neg, p = 0.10	pos, p = 0.15
Tumour stage	pos, p = 0.31	neg, p = 0.30	neg, p = 0.98

Direction of association and adjusted p‐values are given.

^aPer 10%‐point increase.

^bDichotomized into negative (0) and positive (1+/2+).

^cFemale versus male.

^dPer year.

^eFGFR1 and 2 as heavy versus light smoking; FGFR3 as PY.

SCC, squamous cell carcinoma; AC, adenocarcinoma; LCC, large cell carcinoma.