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. 2016 Oct 17;213(11):2349–2364. doi: 10.1084/jem.20160185

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© 2016 Yang et al.

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Figure 3. — Dpy30 KO HSPCs are functionally defective. (A) Colony formation assay using 10⁵ BM cells from Mx1-Cre; Dpy30^F/+ and Mx1-Cre; Dpy30^F/− mice 4 d after the last pIpC injection. n = 3 mice for each genotype. A representative image of the plates with formed colonies is shown on the right. (B) CAG-CreER; Dpy30^F/+ and CAG-CreER; Dpy30^F/− mice were injected with tamoxifen seven times and whole BMs were used in competitive transplantation (donor: competitor = 10:1), and donor contribution to indicated PB cells was determined at different times after transplantation. n = 5 mice for F/+; n = 4 mice for F/−. P < 0.001 for all by Student’s t test. (C) A representative FACS analysis of PB B cells 8 wk after transplantation shown in B. Data are shown as mean ± SD for A and B.