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. 2016 Oct 17;213(11):2503–2523. doi: 10.1084/jem.20160397

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© 2016 Delaunay et al.

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Figure 9. — Model for the implication of the U34 tRNA modifications in breast cancer metastasis. The U34 tRNA-modifying enzymes ELP3 and CTU1/2 are induced in models of invasive breast cancer and are critical for the translation of DEK, which in turn regulates the IRES-dependent translation of the oncogenic LEF-1 mRNA to promote breast cancer cells motility and metastasis. This mechanism is essential for the establishment of a LEF-1–dependent prometastatic genes signature in breast tumors.