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. 2016 Oct 17;213(11):2383–2398. doi: 10.1084/jem.20160438

Figure 4.

Figure 4.

Inhibition of NFAT reduces CpG DNA–induced IFN-α in human primary pDCs. (A) Human primary pDCs stimulated with 1 µM CpG A for 24 h together with FK506 or vehicle (DMSO). Production of IFN-α was measured by ELISA. (B and C) Human primary pDCs stimulated with 1 µM CpG B for 24 h together with FK506 or vehicle (DMSO). Production of TNF-α and IL-6 were measured by ELISA. (D) Human primary pDCs stimulated with 1 µM CpG A for 24 h together with Cs A or vehicle (DMSO). Production of IFN-α was measured by ELISA. (E and F) Human primary pDCs stimulated with 1 µM CpG A for 24 h together with Cs A or vehicle (DMSO). Production of TNF-α and IL-6 was measured by ELISA. Data are representative of four independent experiments.