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K597E does not impair SAM-TIR–dependent neuronal death. (A) Expression of fragment containing the SAM domains and TIR domain from SARM1 induces neuronal cell death. (B) Quantification of neuronal death in cells expressing the indicated SAM-TIR protein. DRGs were also preincubated with 1 mM NR, which suppresses SARM1-dependent cell death. (C) Images of DRG neurons labeled with ethidium homodimer. *P < 0.05. Error bars reflect ± SEM (n = 3). Ctrl, control. (Scale bar, 25 μM.)
