Fig. 6.

SARM1 (K597E) expression prevents axonal NAD⁺ loss after axotomy. (A and B) Axonal NAD⁺ and ATP levels were measured from transected SARM1^−/− DRGs expressing an empty vector, WT SARM1, or SARM1 (K597E). There is a significant drop in axonal NAD⁺ in the presence of SARM1; however, there is no significant decrease in the presence of SARM1 (K597E). (C and D) Axonal NAD⁺ and ATP levels were measured from transected WT DRGs expressing the same constructs as described in A and B. Expression of SARM1 (K597E) delays axonal loss of NAD⁺ and ATP after axotomy. *P < 0.05. Error bars reflect ± SEM (n = 3). N.D, not detectable.