Fig. 7.

Arid5a-deficient mice are protected from T-cell–mediated, IFN-γ–dependent endotoxic shock. (A) Schematic diagram shows the experimental design. Mice were administered heat-killed P. acnes (1 mg in 200 μL PBS) i.p. On day 5, the mice were treated with low-dose LPS (5 μg/mouse). Serum cytokines and the mortality of the mice were analyzed after LPS treatment. (B) Survival analysis of WT (n = 7) and Arid5a-deficient mice (n = 7) after P. acnes-primed LPS treatment (C) Serum was collected 4 h after LPS treatment from WT (n = 4) and Arid5a-deficient mice (n = 4), and the proinflammatory cytokines IFN-γ, IL-6, and TNF-α were measured by ELISA. **P < 0.01, (Student’s t test).