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Expression of the proinflammatory cytokines IL-6 and IFN-γ was significantly decreased in Arid5a-deficient splenocytes after LPS challenge. Twenty-four hours after LPS injection (5 mg/kg; n = 3), spleens were collected from WT and deficient mice, homogenates were prepared, and IL-6, TNF-α and IFN-γ levels were measured by ELISA. Error bars show the means ± SD. *P < 0.05; **P < 0.01; (Student’s t test); N.D., not detected.
