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. 2016 Sep 26;113(41):E6145–E6152. doi: 10.1073/pnas.1607843113

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Fig. 1. — Laquinimod treatment down-regulates genes associated with the Th17 pathway. These boxplots show the patterns of the expression of individual genes from splenocyte samples taken from naive and EAE mice at day 6 postinduction (n = 6 per treatment). It shows the patterns of expression across three conditions: EAE mice treated with vehicle, EAE mice treated with laquinimod, and naive mice treated with vehicle (n = 5). Laquinimod treatment significantly reduced the expression of IL-17a [log₂ fold change (FC): −2.91; FDR: 4.4e-4], Il17re (log₂ FC: −1.64; FDR 7e-3), and Il22ra1 (log₂ FC: −1.81; FDR: 2.7e-3).