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. 2016 Sep 26;113(41):E6145–E6152. doi: 10.1073/pnas.1607843113

Fig. 2.

Fig. 2.

Transcriptome analysis reveals that laquinimod induces genes in the AhR pathway. (A) This heatmap was generated using the patterns of expression of splenocyte samples from EAE mice at day 6 postinduction. It shows the patterns of expression of 88 genes with higher levels of expression in EAE mice treated with laquinimod (green, n = 6) than in EAE mice treated with vehicle (orange, n = 6). (B) This heatmap was generated using the patterns of expression of splenocyte samples from naive mice at 6 d postinduction. It shows the patterns of expression of 45 genes with higher levels of expression in naive mice treated with laquinimod (red, n = 6) than in naive mice treated with vehicle (blue, n = 5). For both A and B, the filters used to define statistical significance were a fold-change > 2 and an FDR < 0.01. Rows were ordered from highest to lowest average fold-change. (C) In vivo induction of hepatic Cyp1a mRNA following 5-d treatment with 25 mg/kg laquinimod in C57BL/6 mice. This graph is taken from a representative experiment, which has been repeated at least four times.