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Decreased response to the glutamate antagonist MK801 in MSN-D2RKO mice. Motor response (cumulative activity count every 10 min) to MK801 of MSN-D2RKO, DA-D2RKO, and WT littermates. MSN-D2RKO show decreased response to MK801 compared with WT and DA-D2RKO mice [genotype effect F(22, 495) = 38.97; P < 0.01]. Values are mean ± SEM (n = 7–11 per treatment per genotype).
