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. 2016 Sep 26;113(41):11609–11614. doi: 10.1073/pnas.1608362113

Fig. 3.

Fig. 3.

Blunted induction of c-fos expression in the absence of D2R in MSNs. (A) Representative dISH using D1R (red) and c-fos (green) specific probes hybridized to striatal sections containing either the DS or VS, as indicated. (Scale bars, 25 μm.) Arrowheads indicate cells that are both c-fos+ and D1R+. (B) Quantifications of the number of neurons positive for D1R and c-fos in the DMS (Left) and in the VS of D2R mutants (Right). DMS: F(3, 10) = 27.20, P < 0.0001 and VS: F(3, 10) = 39.27, P < 0.0001. The (−) and (+) symbols indicate absence or presence of cocaine, respectively. Values are mean ± SEM (n = 3 per treatment per genotype). ***P < 0.001 vs. saline-treated mice of the same genotype; ^^P < 0.01 vs. WT cocaine-treated mice.