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. 2016 Sep 26;113(41):11609–11614. doi: 10.1073/pnas.1608362113

Fig. 4.

Fig. 4.

Cocaine differentially induces ERK and GluR1 phosphorylation in D2RKO and MSN-D2RKO mice. Blunted pERK1/2 induction by cocaine in D2RKO [F(1, 18) = 5.897, P < 0.05] (A) and in MSN-D2RKO striata (B) [F(1, 8) = 39.07, P < 0.001] compared with WT. Cocaine induced GluR1 Ser845 phosphorylation in D2RKO (C) and MSN-D2RKO striatal extracts (D) compared with WT. [D2RKO: genotype x treatment, F(1, 15) = 6.8, P < 0.05; MSN-D2RKO: genotype × treatment, F(1, 14) = 16.69, P < 0.01]. The (−) and (+) symbols indicate absence or presence of cocaine, respectively. Values are expressed as mean ± SEM (n = 4–5 per treatment per genotype). ***P < 0.001, **P < 0.01, *P < 0.05 vs. saline-treated mice; ###P < 0.001, ##P < 0.01 vs. WT cocaine-treated.