Fig. 4.

Progressive loss of motor and sensory axons is observed in PFN1^C71G mice but not in nTg and PFN1^WT mice. (A and B) The cross-sections of the whole L5 ventral and dorsal roots at different ages (days) as well as an enlarged area from these roots are shown. The ventral root degeneration in PFN1^C71G mice precedes the degeneration of dorsal root. Arrows indicate degenerating axons. (C and D) Quantification of L5 ventral and dorsal root axon numbers, respectively, is shown. The axon numbers in the ventral and dorsal root of nTg and PFN1^WT mice are relatively constant at different ages (Fig. S4B) and thus are grouped together. The range of ages for each group is shown under each bar. Statistics and significance levels are the same as in Fig. 3. (E) Quantification of degenerating axons in ventral and dorsal root axons, respectively, is shown. Disease stages: <120 d, presym; 121–140 d, swk; 141–170 d, Wk; 171–200 d, Wk to ppar; and 201–230 d, par. The bars in C–E represent averages from three to nine mice. All error bars are SE.