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. Author manuscript; available in PMC: 2016 Oct 18.
Published in final edited form as: Nat Neurosci. 2016 Sep 27;19(10):1292–1298. doi: 10.1038/nn.4378

Figure 2.

Figure 2

Projected mechanisms that can control the life of a single RNA gene, perhaps at a single-molecule level. (a) RNA-binding proteins control many facets of RNA biology. RNA–protein interactions can be controlled by chemical modifications (m6A, for example). The interplay between physical changes to RNA and protein binding is therefore complex and affords many opportunities for potential regulation (RBP: RNA-binding protein). (b) Structure switching is a key mechanism that can either inhibit or enhance protein binding. (c) Schematic demonstrating N6-methylation of adenosine, which has been shown to lead to RNA decay. (d) RNA editing can result in the expression of an altered protein. This figure demonstrates A-to-I editing, which can alter codon identity, leading to a protein with an altered sequence.