Table 2.
Numbers of children in the three cohorts with neurological sequelae. Diagnoses were counted per child. The primary diagnoses were classified according to severity in the ranking order system. Diagnoses were recorded from 1 January 1995 to 31 December 2002
| Neurological sequelae | IVF-ICSI twins (n=3393) | Control twins (n=10 239) | P value (Pearson's χ2 test) | IVF-ICSI singletons (n=5130) | P value (Pearson's χ2 test) |
|---|---|---|---|---|---|
| Mental retardation | 4 | 14 | 0.8 | 9 | 0.5 |
| Infantile autism | 3 | 8 | 0.9 | 8 | 0.4 |
| Asperger's syndrome | — | 3 | 0.4 | — | — |
| Retarded psychomotor development | 12 | 32 | 0.7 | 12 | 0.3 |
| Cerebral palsy | 11 | 41 | 0.5 | 13 | 0.5 |
| Total | 30 (8.8/1000) | 98 (9.6/1000) | 0.7 | 42 (8.2/1000) | 0.7 |
Neurological sequelae were defined as mental retardation and severe mental developmental disturbances (DF70.0-DF79.9, DF 84.0-DF89.9) including infantile autism (DF84.0) and Asperger's syndrome (DF84.5), cerebral palsy (DG80.0-DG83.8), and retarded psychomotor development (DR62.0).