Table 3.
Odds ratio of neurological sequelae, cerebral palsy and mental retardation in IVF-ICSI twins versus control twins and IVF-ICSI singletons. Results are presented as odds ratios and adjusted odds ratios for child sex and year of birth with 95% confidence intervals
| No of children | No of children with disorders | Odds ratio (95% CI) | Adjusted odds ratio (95% CI)* | |
|---|---|---|---|---|
| Cerebral palsy | ||||
| IVF-ICSI twins | 3393 | 11 (0.3%) | 1 | 1 |
| Control twins | 10 239 | 41 (0.4%) | 1.2 (0.6 to 2.4) | 1.2 (0.6 to 2.3) |
| IVF-ICSI singletons | 5130 | 13 (0.3%) | 0.8 (0.4 to 1.8) | 0.8 (0.4 to 1.8) |
| Mental retardation diagnoses | ||||
| IVF-ICSI twins | 3393 | 19 (0.6%) | 1 | 1 |
| Control twins | 10 239 | 57 (0.6%) | 1.0 (0.6 to 1.7) | 1.0 (0.6 to 1.7) |
| IVF-ICSI singletons | 5130 | 29 (0.6%) | 1.0 (0.6 to 1.8) | 1.1 (0.6 to 1.9) |
| Neurological sequelae (total) (Cerebral palsy+mental retardation diagnoses) | ||||
| IVF-ICSI twins | 3393 | 30 (0.9%) | 1 | 1 |
| Control twins | 10 239 | 98 (1.0%) | 1.1 (0.7 to 1.6) | 1.1 (0.7 to 1.6) |
| IVF-ICSI singletons | 5130 | 42 (0.8%) | 0.9 (0.6 to 1.5) | 1.0 (0.6 to 1.5) |
*
Adjusted for child's sex and year of birth.