Table 4.

Multiple logistic regression analysis showing independent effects of being a twin infant, assisted conception (IVF and ICSI), maternal age ≥35 years, male sex, and low birth weight (<2500 g) (upper panel) or low gestational age (<37 weeks) (lower panel) on the risk of neurological sequelae and cerebral palsy. Results are presented as odds ratios (95% confidence intervals), adjusted for child sex and year of birth

	Neurological sequelae		Cerebral palsy
	All cases	Twins	All cases	Twins
Effects of birth weight
Twin	0.7 (0.4 to 1.2)	—	0.6 (0.2 to 1.4)	—
Assisted conception	0.9 (0.6 to 1.4)	0.9 (0.6 to 1.4)	0.8 (0.4 to 1.5)	0.8 (0.4 to 1.5)
Low birth weight	2.3 (1.6 to 3.2)	1.9 (1.4 to 2.8)	4.4 (2.5 to 7.8)	3.0 (1.7 to 5.4)
Male sex	2.0 (1.4 to 2.8)	1.9 (1.3 to 2.8)	1.9 (1.1 to 3.2)	2.0 (1.1 to 3.5)
Maternal age ≥35 years	0.8 (0.6 to 1.2)	0.8 (0.5 to 1.4)	0.8 (0.4 to 1.5)	0.8 (0.4 to 1.7)
Effects of gestational age
Twin	0.8 (0.5 to 1.3)	—	0.6 (0.2 to 1.4)	—
Assisted conception	0.9 (0.6 to 1.4)	0.9 (0.6 to 1.4)	0.8 (0.4 to 1.6)	0.8 (0.4 to 1.6)
Low gestational age	2.0 (1.4 to 2.8)	1.8 (1.2 to 2.6)	4.5 (2.5 to 8.1)	3.1 (1.7 to 5.7)
Male sex	1.9 (1.3 to 2.6)	1.8 (1.2 to 2.6)	1.8 (1.0 to 3.0)	1.9 (1.0 to 3.4)
Maternal age ≥35 years	0.8 (0.6 to 1.2)	0.8 (0.5 to 1.4)	0.8 (0.4 to 1.5)	0.8 (0.4 to 1.8)