Table 1.
Methylation level ΔCp of PAX1 detected by qMSP and PMR detected by AuNP-labeled method at various disease stages
| Pathology | Case number | qMSP
|
AuNP-labeled method
|
||
|---|---|---|---|---|---|
| Median (∆Cp) | SD | Median (PMR %) | SD | ||
| Normal | 12 | 15.0 | 6.069 | 33.11 | 0.149 |
| CIN1 | 13 | 14.9 | 6.175 | 45.14 | 0.295 |
| CIN2 | 7 | 8.9 | 9.873 | 74.64 | 0.309 |
| CIN3 | 7 | 4.2 | 3.626 | 67.81 | 0.298 |
| SCC | 3 | 3.9 | 2.230 | 82.64 | 0.074 |
Abbreviations: AuNP, gold nanoparticle; CIN1, cervical intraepithelial neoplasia type 1; CIN2, cervical intraepithelial neoplasia type 2; CIN3, cervical intraepithelial neoplasia type 3; qMSP, quantitative methylation-specific polymerase chain reaction; PMR, percentage of methylated rate; SCC, squamous cell carcinoma; SD, standard deviation.