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. Author manuscript; available in PMC: 2016 Oct 18.
Published in final edited form as: DNA Repair (Amst). 2016 Jan;37:A3–A13. doi: 10.1016/j.dnarep.2015.12.002

Fig. 2.

Fig. 2

NER in the mid-1980s. By 1985 NER was known to proceed as a dynamic process of damage recognition and incision involving endonucleolytic incisions flanking the damaged site, excision of the oligonucleotide, simultaneously with repair synthesis. Finally, restoration of the repair patch into full length DNA was achieved with a ligase. The molecular steps were known, but the action of each protein was not.