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. Author manuscript; available in PMC: 2016 Oct 18.
Published in final edited form as: DNA Repair (Amst). 2016 Jan;37:A3–A13. doi: 10.1016/j.dnarep.2015.12.002

Fig. 3.

Fig. 3

Working model for the repair of inter-strand DNA cross-links in bacteria. The UvrABC proteins were shown to incise on one side of a psoralen cross-link. This gapped substrate was processed by a RecA filament to generate a three-stranded intermediate. In a second round of incisions, UvrABC was shown to act on the psoralen-cross-linked-excised oligonucleotide. Gap filling by DNA polymerase I and ligation complete the repair process. This incision/recombination/incision model is based on a previous model of Cole [38]. From Ref. [76] with permission.