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. Author manuscript; available in PMC: 2016 Oct 18.
Published in final edited form as: DNA Repair (Amst). 2016 Jan;37:A3–A13. doi: 10.1016/j.dnarep.2015.12.002

Fig. 4.

Fig. 4

Bacterial NER in the 1990s. Many of the key steps mediated by the UvrA, UvrB and UvrC proteins were becoming known: UvrA and UvrB work together to recognize the lesion. In an ATP-dependent step, UvrB engages the damaged nucleotide causing strand opening allowing UvrA to dissociate. Recruitment of UvrC causes dual incisions 5′ and 3′ to the damaged site. The dual action of UvrD and Pol I are necessary for gap filling and turnover of UvrB and UvrC from the post incision complex. Finally DNA ligase works to seal the newly completed repair patch. From Ref. [76] with permission.