Fig. (2).

Deacetylation and miRNA dysregulation in PCa. (i.) In normal cells, miR-449a is involved to regulate cell growth by repressing the expression of HDAC-1 that allows the expression of p27/kip 1 (ii.) in PCa cells (PC-3), miR-449a gene is down-regulated by HDAC1, which represses its expression. The loss of miR-449a expression maintains HDAC-1 expression activated; this leads to p27/kip1 silencing that promotes cancer cell viability and growth [90]. [List of abbreviations: PCa, prostate cancer; HDAC, Histone deacethylase].